One of the perks of belonging to the worlds smartest genus of mollusks is that you can learn, through experience, what things are safe, and what things are not. The bad news is that on her walkabout, Isis learned that something about you and/or the world outside the tank is dangerous. The good news is that after repeatedly associating you with food (the ultimate good thing) that same brain will rightly conclude that while the world outside the tank might be dangerous, you are a very nice lady (who brings dinner!). It's inevitable that she'll come to like and trust you again. My current bimac was nearly an adult when I caught it, and didn't take the transition to my tank very well. He chewed the tips of his tentacles off, refused food, hid a lot, and inked easily. After three or four weeks, he settled down, started eating, and within a couple of months he was literally eating out of my hand. He's been doing great, and likes me just fine.