Hi there Oktoputeao,
There are plenty of molluscs that have adapted to a fresh water existence, slugs and snails even made it on to land, but cephalopods for one reason or another over the almost 480 million years of their evolution have done neither. The same applies to echinoderms; an entire phylum sealocked. This could all change one day, but it simply hasn't yet. It may only take a few random quirks to the genome and Bob could very well be your uncle.